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The aforementioned results are analogous to those found in chronically treated Npc1−/− mice and demonstrate that Npc2−/− mice also benefit from treatment with CD.
Do therefore mice also benefit from improved tumor suppression?
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Positive results from the CD treatment study in NPC1 disease led us to hypothesize that Npc2−/− mice might also benefit from treatment, as NPC2 disease is similarly characterized by cholesterol and GSL accumulation and the two NPC proteins may function in the same metabolic pathway [9], [10].
Thus, it appears that human tumor cells can also benefit from orthotopic mouse tissue implantation quite similarly to the mouse tumor cell lines.
However, transplantation experiments in nude mice suggest that effects of RANTES may also benefit tumour progression.
Consumers also benefit.
Patients also benefit.
Development agencies can also benefit.
Higher earners would also benefit.
Samantha Cameron may also benefit.
Developers also benefit from time savings.
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