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The use of immunodeficient mice allows us to address the question of whether an infection arising from a single infected cell will transcribe the same family members, in the absence of any selection pressure applied by the developing specific immune responses.
The ability to measure efficacy in both the brain and plasma compartments in the transgenic mice allows us to probe whether total or free concentrations of compound drives efficacy.
The recent availability of reproductive tissue-specific expression profiles for humans and mice allows us to monitor gene co-expression and predict plausible new meiotic genes that are important in human reproduction [ 6- 9, 15, 16].
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The present study, in which we used Gsdma KO mice, allowed us to observe the precise expression pattern of Gsdma3 without influence of Gsdma.
The use of deficient mice allowed us to demonstrate that PAI-1 is essential for angiogenesis while the absence of an MMP, MMP-11, did not affect vessel sprouting.
Importantly, the use of iNOS−/− mice allowed us to provide genetic evidence for iNOS-dependent IRS-1 tyrosine nitration in skeletal muscle in vivo.
The use of larger cohorts of mice allowed us to confirm the above results also statistically.
In this study, the use of B6-ChrNMSM consomic panel mice allowed us to identify an extensive number of chromosomes related to anxiety-like behaviors because of the large genetic distance between B6 and MSM.
We describe the generation of a conditional knockin mouse line that, crossed with serotonin-specific Cre-recombinase mice, allowed us to remotely stimulate serotonergic neurons during fMRI scans.
Interrogation of neurosphere-derived cells (from four patients) and cells derived from secondary transplants of these same cells in NOD-SCID mice allowed us to infer the clonal and phylogenetic architectures.
HPLC-MS/MS quantification in brain homogenates and MALDI-TOF mass spectrometry imaging on brain tissue sections performed in MPAQ-treated mice allowed us to confirm this prediction and to demonstrate, by MALDI-TOF mass spectrometry imaging, that MPAQ was localized in areas containing vulnerable neurons and/or their terminals.
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CEO of Professional Science Editing for Scientists @ prosciediting.com