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Before the sample sizes were quite low in most cases, but the additional data obtained from EAAT4-eGFP mice allow us to make a better comparison.
We suggest that altering the SL composition induces contractile dysfunction via KCa1.1 upregulation in aged GSM, and CerS2‐null mice allow us to investigate age‐associated contractile dysfunction in GSM.
These unique mice allow us to further our understanding of ALS by separating the central motor neuron body degeneration and the peripheral effects from a fALS mutation expressed at endogenous levels.
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The use of immunodeficient mice allows us to address the question of whether an infection arising from a single infected cell will transcribe the same family members, in the absence of any selection pressure applied by the developing specific immune responses.
The present study, in which we used Gsdma KO mice, allowed us to observe the precise expression pattern of Gsdma3 without influence of Gsdma.
The use of deficient mice allowed us to demonstrate that PAI-1 is essential for angiogenesis while the absence of an MMP, MMP-11, did not affect vessel sprouting.
Importantly, the use of iNOS−/− mice allowed us to provide genetic evidence for iNOS-dependent IRS-1 tyrosine nitration in skeletal muscle in vivo.
The use of larger cohorts of mice allowed us to confirm the above results also statistically.
In this study, the use of B6-ChrNMSM consomic panel mice allowed us to identify an extensive number of chromosomes related to anxiety-like behaviors because of the large genetic distance between B6 and MSM.
We describe the generation of a conditional knockin mouse line that, crossed with serotonin-specific Cre-recombinase mice, allowed us to remotely stimulate serotonergic neurons during fMRI scans.
Interrogation of neurosphere-derived cells (from four patients) and cells derived from secondary transplants of these same cells in NOD-SCID mice allowed us to infer the clonal and phylogenetic architectures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com