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We hypothesized that maternal caffeine ingestion during pregnancy and the early postnatal period in mice affects the construction and activity of cortical networks in offspring.

Not surprisingly, expression of oncogenes in Arf-/ transgenic mice affects the timing and characteristics of the tumors that arise.

As mice expressing SOD1H46R exhibited progressive motor dysfunction and paralysis, particularly of the hind limbs, we next assessed whether loss of ALS2 in SOD1H46R mice affects the course of motor deficits by conducting quantitative behavioral analyses.

Although administration of CIM to mice affects the synthesis and degradation of haem, no alteration in catalase activity had been described so far (Baird et al, 1987).

Our study is the first one to demonstrate that DES neonatal treatment in male and female mice affects the immune cell percentage, without effect on the susceptibility to T. crassiceps cysticercosis.

Thus, we assessed how COMP deficiency in Apo E knock out mice affects the development of inflammatory and fibrous carotid plaques and also spontaneously developing plaques in the brachiocephalic artery, with focus on collagen fibre formation.

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The results showed that TSRDN could inhibit the lung tissue expression of α-SMA in asthmatic mice, affect the skeletal muscle thickening, and improve the airway remodeling status.

Indeed, genetically-induced alterations of the 5-HT system in mice affect the RRG responses to CO2/pH, as reported in SERT knockout mice [37], [52] and lmx1b and Pet-1 knockout mice [53], [54].

Finally, we assessed whether the addition of cholesterol to hippocampal slices prepared from young mice affected the distribution of MARCKS.

To investigate whether reduced SIRT1 expression in the SIRT1+/− mice affected the levels of SIRT1-dependent genes altered by CR in the liver, we performed microarray analyses.

We also noticed that the reduced activation of AMPK in hepatocytes from LKB1C433S/C433S-knockin mice affected the phosphorylation of raptor, but not ACC.

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