At necropsy, no visible pathological changes were noted in the livers and kidneys of mice administered EEGE at 100, 200 and 300 mg/kg doses.
Besides the number of LF detected in the salivary glands of the experimental animals, immunofluorescent staining to detect B and T cells revealed further differences in the cellular composition of the infiltrations between mice administered Ad5-IL17A an an early or late stage.
This event has been demonstrated also in mice administered with cisplatin at doses that reproduce those used in humans.
Diabetic wounds of mice administered with vehicle at day 12 showed poor-to-mild re-epithelialization with partially organized granulation tissue.
Similar, yet more pronounced, results were observed in mice administered rAAV2- IL27 at 14 weeks of age, the time of adaptive immunity onset in the C57BL/6.NOD- Aec1Aec2 mice.
The vaccine formulation did not induce any mortality even when mice were administered at 8 × 109 CFU per oral or per subcutaneous (SC), which was 100-times more than the actual vaccine dose intended for mice model.
The antitumour efficacy of seliciclib has been demonstrated in human tumour xenografts in nude mice, when administered at 500 mg kg−1 twice a day or 200 mg kg−1 thrice a day (McClue et al, 2002; Raynaud et al, 2005).
We observed >2-fold increase in the incidence of lung metastasis in the arthritic versus non-arthritic PyV MT mice (7/10 mice with CII administered at 18 wks, and 9/13 mice with CII injected at 9 wks) compared to the PyV MT mice with no CII (3/11 mice).
The drugs caused widespread brain cell death in human cancer cell cultures and in live mice, even when administered at low levels, the researchers found.
According to the experiments on mice for the development of vaccine, efficient replication of the virus is found in the respiratory tract of the mice after they are administered at a very low dose of the SARS-CoV [ 47, 48], indicating high infectivity of the SARS-CoV.
