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The seroprotection rate (SPR, %) was calculated from the proportion of mice achieving a post-vaccination titer ≥40.
In contrast, the infection was controlled in lungs of untreated mice, achieving a steady state of about 6 log10 bacilli from 28 days post-infection to the end of the experiment (Figure 6A).
When the amount of virus administrated was increased to 5 µg HA (Figure 2D), the mean HI titer was slightly higher than 40 in the group when the mice immunized once with inactivated virus alone, however, the seroprotection rate (mice achieving a post-vaccination titer ≥40) never reached 100%.
When mice are dichotomized according to the RMCBS, mice achieving a RMCBS of 0 15 (n = 6) demonstrate a total hemorrhage count of 1014, versus the cohort achieving a RMCBS of 16 20 (total n = 22 minus 6 control = 16 experimental) with a total hemorrhage count of 59 (p<0.0001, Mann-Whitney U) (Figure 8B).
We found that a CR diet did not rescue the short lifespan of the UbC-RKO mice, despite UbC-RKO mice achieving a similar weight loss compared to wild-type mice on a CR diet.
Yet, isolation and inbreeding can cause fast divergence in this fraction of time, as shown by insular population of mice achieving a significant differentiation in a similar amount of time [ 1].
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For this study, the oncolytic vaccinia virus GLV-1h255, conthening the mmp-9 gene, was constructed and used to treat PC-3 tumor-bearing mice, achieving an intra-tumoral over-expression of MMP-9.
Thus, it was extremely interesting to note that in spite of the fact that Inv-Cldn6-CΔ196 Inv-Cldn6-CΔ196 Inv-Cldn6-CΔ196 epidermiceby one-month of achieve morphology and biochemical markers), with aging they have a high propepidermisr epidermal injury and a diminished abylity to repair lesions, leading eventually tofsevere dermagetis with associated changes in skin byrrier function.
If mice achieved a grade 4 reading on two consecutive days they were euthanised.
The combination treatment, at a non-myeloablative dose, that was maximum tolerated by beige-nude-xid mice induced CRs in 100% of the MM.1S and OPM-2 xenografts, while 25% of mice achieved a CR in KMS-12-PE xenografts.
Repeated transfection of the human HGF gene into skeletal muscle of chronic GVHD mice achieved a plasma HGF level (human and mouse HGF) between 1.07 and 1.35 ng/ml during the 12 week period after GVHD induction.
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