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Finally, in the homozygous conditional Dicer mutant mice a substantial proportion of fibers extended into the contralateral optic nerve, after they had crossed the midline.
However, in Ro52-deficient mice a substantial increase in IRF7 induction was observed, which peaked at 6 hrs following imiquimod stimulation and at 3 hrs following CpG-B stimulation.
However, in female mice, a substantial number of EYFP-positive cells was also present among HY+ IEL that were either DN or CD8αα suggesting that induction of these atypical lineages could have occurred at the DP stage.
In homozygous WHSC1 −/− mice, a substantial proportion of OHCs and IHCs lacked kinocilia or stereocilia (Fig. 7D-J; supplementary material Fig. S3G,M; asterisk).
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It is therefore paradoxical that in mouse a substantial amount of maternal rRNA and ribosome are degraded during oocyte maturation prior to fertilization [60], [61].
It is noteworthy that in a recent large-scale analysis of the intrinsically disordered proteome of mouse, a substantial number of disordered proteins are predicted to have coiled-coil motif presence in their sequences.
Immunized mice showed a substantial reduction in the vaccinia virus titer compared with control mice when the immunized mice were challenged with a recombinant vaccinia virus expressing HCV-NS5a genes.
Transplanted animals also presented with a preservation of axonal density in the L4 ventral root, while control mice showed a substantial reduction in axons compared with wild-type mice.
Interestingly, despite both MSTN+/− and MSTN−/− mice demonstrating a substantial increase in Po (Fig. 1I), only the MSTN+/− mice had an increase in sPo (Fig. 1J).
K14Cre Rac1F/F mice showed a substantial delay in wound healing with a median healing time of 13 days compared to control mice that healed in 9 days (Figure 1A).
Elhage et al. reported that IL-18−/−/ApoE−/− mice exhibited a substantial, 35% reduction in lesion size when compared with IL-18-competent littermates, while the compound knockout mice displayed reduced I-Ab gene expression, implying reduced local IFN-γ stimulation.
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