Because of the high conservation of the DREAM complex, we expected to observe in mouse a pattern of E2F4 binding similar to that found in human, with a common set of genes bound independent of the particular tissue, and enriched for proliferation-related pathways.
On day 3 after CY treatment, R4A Tg-BALB/c mice displayed a greater than 95% loss of splenic B cells, and thereafter mice exhibited a pattern of B cell reconstitution similar to that exhibited by WT BALB/c mice (Table 3 and Figure 1A).
These results suggest that Nrf2−/− mice exhibit exacerbated basal and MPTP-induced gliosis and that HO-1−/− mice show a pattern of gliosis similar to their wild type littermates.
But after a week on high-fat chow, the experimental mice had a pattern about 20 minutes shorter than normal.
Corn oil treated mice exhibited a pattern of response similar to olive oil.
PMA caused neuronal cell death in the wild-type mice with a pattern very similar seen in rats.
Leptin, an adipokine with proinflammatory activity, was increased systemically in high-fat-fed mice following a pattern that was similar to the temporal changes in body mass.
Bone morphometric analysis of Ts65Dn mice revealed a pattern of craniofacial anomalies similar to those seen in individuals with DS, including a smaller flattened face, brachycephaly, a flattened occiput and a smaller mandible (Richtsmeier et al., 2000).
Thus, both the quantity of cholesterol and its distribution among lipoprotein fractions are shifted in the knockout mice to a pattern known to be associated in humans with risk of atherosclerosis.
