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Egr-2 cKO mice, a line with deletion of Egr-2 in CD2+ lymphocytes on a B6 background, were described in our previous publication [16].
However, C57Bl/6 mice, a line responding to food restriction, resemble DBA/2 if this criterion was applied [ 40].
A line of Ar (also known as Akr1b3 -knockout (KO) mice, a line of Ar-bitransgenic mice and control C57BL/6 mice were used in the study.
To visualise specifically the structure and not only the activity of the mitochondria, we crossed Drp/MC transgenic mice with PhAM transgenic mice, a line with photo-activatable mitochondria.
In this study, using a similar approach, we explored the role of the pro-neurotrophin co-receptor sortilin in the progression of neurodegeneration in AD10 anti-NGF mice, a line of transgenic mice in which anti-NGF antibodies are obligatorily expressed in lymphocytes and therefore are initially only found in serum and later, after disruption of the blood brain barrier, also in the brain [8].
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To do so, they created a mouse line expressing cre-recombinase under control of the neuronal glucokinase promotor and crossed mice with a line expressing an EGFP-tagged ribosomal construct.
The triadin KO mouse, a mouse line devoid of any triadin isoform, has been previously shown to present both cardiac arrhythmia (8) and muscle weakness (9).
We then describe an in vivo gain-of-function genetic experiment using a mouse line carrying a functional Map3k4 bacterial artificial chromosome (BAC) transgene.
We therefore decided to promote normal adenosine metabolism in mouse glomerulus by generating a mouse line over-expressing ADA in podocytes.
To determine the role of Cdc42 in heart development, we created a mouse line by crossing Cdc42/flox mice with MLC2a-Cre mice, which inactivated Cdc42 in the embryonic cardiomyocytes [22].
Previous studies have suggested that, in a mouse line with a constitutive DAT knockout, cocaine self-administration can still be established [26], [27] while the constitutive D1 receptor knockout mouse line showed no such behavior [28].
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