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Seizures were studied in Synapsin I/II double knock-out (SynDKO) mice, a genetically engineered mouse line that shows seizures upon daily handling procedures such as tail lifting during cage changes, much in resemblance to the more studied El mouse.
Then they implanted into the mice a genetically engineered line of cancer cells festooned with ovalbumin protein.
This was accomplished by using in vivo fluorescence imaging of LysEGFP mice, a genetically engineered mouse strain that possesses green-fluorescent neutrophils [47], [48].
In some experiments, 12-week old male LysEGFP mice, a genetically engineered mouse line on a C57BL/6 background possessing green-fluorescent myeloid cells (mostly neutrophils) as a consequence of 'knockin' of enhanced green fluorescence protein (EGFP) into the lysozyme M gene, were used [47], [48].
On the other hand, skin AHH activity is never induced by methylcholanthrene in DBA/2J mice, a genetically non-responsive strain.
The Rgs16::GFP transgene is a Kras G12D -dependent marker of all stages of PDA neoplasia and its expression increases proportionally to tumor burden in KIC mice – a genetically engineered mouse model of PDA.
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Genetic mapping using collaborative cross mice (CC), a genetically diverse recombinant inbred mouse reference panel, offers a powerful tool to identify causal loci at a resolution under one mega base-pairs, with a relatively small cohort size.
Anp32b-deficient mice demonstrated a strain-dependent penetrance of perinatal lethality with surviving mice in a genetically mixed background showing growth defects, premature aging, and a wide array of pathologies 101.
We used ouabain as prototypic digitalis drug; transverse aortic constriction (TAC) to induce pressure-overload and pathological hypertrophy; and we compared the effects of ouabain treatment on the development and the consequences of TAC in the wild type mouse and a genetically modified mouse from which cardiac PI3Kα was deleted but exhibited normal cardiac contractility and histology [ 16].
Unlike salamanders, mice offered a genetically well-documented animal model with which to study limb regeneration.
Labs elsewhere have reported that two additional types of mice, including a genetically engineered strain, are also Methuselahs.
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