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Transgenic mice with this version of HIF-1 had about 66% more capillaries than control mice, a difference visible to the naked eye, the team reports in the 1 October issue of Genes and Development.
Immunization with P. berghei IrrSpz reduced by 57% P. yoelii liver load as compared to non-immunized mice, a difference that did not reach statistical significance.
At a histological level, when administered to either 5-wk or 20-wk mice, a difference in the quantitative liver (p = 0.28 0.84) or lung (data not shown) cytopathies was not observed when comparing the effects of either GCase.
Thus, monocytes/macrophages during differentiation in vivo may be more sensitive to incretins than cultured macrophages obtained after differentiation in untreated Apoe−/− mice, a difference that could be due to the high levels of the two incretin receptors in monocytes.
Interestingly, GAD65 is a known humoral autoantigen in human T1DM patients but was not thought to be so in NOD mice, a difference that has led to suggestions that the NOD mouse may be an incomplete model of human disease.
The serum lipid profile in LKO was also equivalent to controls, with only HDL cholesterol being marginally elevated in low fat-fed LKO mice, a difference that was lost on high-fat feeding.
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At the BBB, Mct1 contributes to the supply of ketone bodies as an alternative source of energy to the brain, and thus the lower expression of Mct1 in C57BL/6J mice suggests a difference in brain energy metabolism compared to FVB mice.
Following the extensive stress, however, tg mice exhibited more consistent and robust anxiety-like behavior in all the indices examined when compared to control-naïve mice, and a significant difference in all the indices between tg-naïve and tg-36-shock mice, and a difference in most indices between tg-1-shock and tg-36-shock tg mice.
It must be noted that the number of buried layers within atherosclerotic lesions were not different between TIMP-1 and TIMP-2-deficient mice, although a difference was observed between the TIMP-1 and TIMP-2 wild-type controls.
In 12 months old mice, however, a difference was detectable.
The same subsets from non-autoimmune NOR and BALB/c mice exhibit a difference in total levels of CD40 compared to each other but they both induce Bcl-XL expression.
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