Between 3 and 5 h after a systemic LPS injection all mice showed a decline in burrowing, with a greater decline in activity in aged mice compared to young mice (Fig. 5A) (LPS group: p < 0.001, n = 14 15).
Because p16Ink4a-KO mice die of cancer long before they reach the age at which most normal mice experience a decline in SMG function, it is difficult to know whether dysregulation of the Bmi-1/p16Ink4a Bmi-1/p16Ink4apathwaye for the agisg-associated decline of SMG function.
We therefore attempted to determine whether mutant mice displayed a decline in mental faculties.
The only premature defect we were able to identify in the colon of Hnf4α null mice was a decline in ion transport.
Interestingly, the gender dependant effects on γ-secretase activity appear to be specific for APP processing as both male and female mice exhibited a decline in Notch1 γ-secretase activity during aging and exhibit no gender associated differences at 24 months.
Aged mice showed a decline of ATG7 protein and, concurrently, of LC3 lipidation when compared to young animals.
Interestingly, although Plin-5 knockout mice showed a decline in cardiac function with age, they were resistant to STZ-induced cardiac dysfunction (116).
As in the rat model, these diabetic mice showed a decline in podocyte number 2 weeks after the final STZ injection (Fig. 3).
This is further supported by observations of Koki and Masferrer (2002) that nude mice showed a decline in mammary tumour growth continuously throughout a 3-week treatment with celecoxib.
