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Researchers found that the bacterial treatment to be effective only against relatively small tumors in immunocompromised nude mice; a complete regression of established tumors in immunocompetent hosts has been described rarely thus far (Friedlos et al. 2008; Hu et al. 2009; Nagakura et al. 2009).
In mice a complete lack of ACE does not reproduce renal tubular dysgenesis; ACE knock-out mice are hypotensive and are unable to effectively concentrate urine.
When each venom was mixed with derivatives (90 μM) and then injected into mice, a complete protection from hemorrhage was seen (data not shown).
In the doubly deficient mice a complete absence of the adaptive immune response could have led to a more predominant role for the innate immune system in the regulation of the antibody-mediated inflammatory response.
At 7 days after the onset of hind-limb dysfunction in βLKB1KO mice, a complete loss of myelin staining and the disappearance of axons was observed in the thoracic region of the spinal cord (Fig. 2Ad,Ai,C,D).
Although comparable amounts of GFP-expressing hepatocytes were detected in the mice reconstituted with naive cells or cells derived from tolerant (IDLV.142T-treated) mice, a complete clearance of GFP+ hepatocytes was observed in recipient mice reconstituted with cells derived from control, unregulated IDLV-treated mice, and this was accompanied by a loss of vector DNA.
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Moreover, a significant reduction in metastasis formation was observed in LOX + gemcitabine-treated mice (2/13 mice), while a complete absence of metastasis was observed in the mice treated with LOX-blocking antibody (Table 1).
For mouse, a complete list of mitochondrial genes was obtained from mitoRES (732 genes).
These studies are supported by the observation that Cnga3−/− mice show a complete loss of cone response, while Cngb3−/− mice have a residual cone function (30, 31, 35).
Furthermore, heterozygous knockout mice showed almost normal pools of PGCs, whereas homozygous mice exhibited a complete loss of PGCs, suggesting that the expression of Nanos3 from a single Nanos3 allele is sufficient to maintain the number of PGCs (data not shown).
Immunohistochemical analysis showed that control mice expressed both CMAH and Neu5Gc epitopes, whereas Cmah-null mice showed a complete deficiency of both CMAH and Neu5Gc epitopes in liver tissues (Supplementary Figure 1(C)).
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