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A combined total of 1323 isolates were reported with a minimum inhibitory concentration (MIC) range of ≤0.001 1 μg/mL and a maximum MIC for inhibition of 90% of organisms (MIC90) of 0.5 μg/mL, which are far below the fidaxomicin levels found in feces after treatment.
In our data, this phenomenon was not only present in MRSA strains, more frequent in IE than in BSI, in which hVISA were found in well-described nosocomial clones belonging to the agr type II [ 18] with vancomycin MIC of 1 2 mg/l, but also in MSSA, in a lower MIC range of 0.5 1 mg/l.
The combined results of 8 in vitro studies of 1323 C. difficile isolates showed the minimum inhibitory concentration (MIC) range of fidaxomicin to be ≤0.001 1 μg/mL, with a maximum MIC for inhibition of 90% of organisms (MIC90) of 0.5 μg/mL.
These easily accessible, small molecules were found to exhibit in vitro activity against Mycobacterium tuberculosis H37Rv in a MIC range of 0.78 μg/mL to 25 μg/mL.
Lasiodipline E (5) was demonstrated to be antibacterial against the clinical strains Streptococcus sp., Bacteroides vulgates, Peptostreptococcus sp. and Veillonella parvula, respectively, with an minimum inhibitory concentration (MIC) range of 0.12 0.25 μg/mL.
The peptide exhibited a minimal inhibitory concentration (MIC) range of 2 128 mg/L against 28 clinical Escherichia coli, Klebsiella pneumoniae and Salmonella enterica serovar Typhimurium strains, with a median MIC of 30 mg/L.
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Mycoplasma pneumoniae and Legionella pneumophila showed MIC ranges of 0.004 0.125 μg/mL and 0.004 0.03 μg/mL, respectively.
RIF and INH showed a decreased activity against the drug-resistant stains partially or completely with MIC ranges between 2 and > 32 μg/mL (Table 2), while compound 7g afforded a potential effect against MDR strains with comparable MIC ranges of 0.25−1 μg/mL.
The acceptable MIC ranges of the drugs were 0.0047-0.0095 and 0.05-0.1 μg/mL respectively [ 16].
Compound 8 and 4 exhibited the highest antibacterial and antifungal activities with MIC ranges of 2 8 μg/ml and 4 32 μg/ml respectively.
Plant compounds are usually classified as being antimicrobial based on MIC ranges of 100 to 1000 μg/ml while, those of typical antibiotics produced by bacteria or fungi are acceptable antimicrobials at much lower ranges of MICs between 0.01 and 10 μg/ml [[ 25]].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com