Sub-MICs (½ and ¼ MIC) of disinfectants solutions were tested for biofilm inhibition capacity.
One extract exhibited an MIC of 62 μg/mL, and another exhibited an MIC of 15 μg/mL [ 16].
Fractional inhibitory concentration indices (FICIs) were calculated as MIC of drug X (in combination) / MIC of drug X alone + MIC of drugY (in combination) / MIC of drugY alone.
A 2-log10 reduction in log10 ratio would require free drug %T > MIC of 58% or AUC24/MIC of 86.
MIC of amphotericin B against C. albicans was found to be 99 µg/mL whereas, purified compound was effective at much lower MIC of 1 µg/mL.
The FIC is the minimum inhibitory concentration (MIC) of the drug in combination divided by the MIC of drugs acting alone.
The efficacy of 1× MIC of H1 and H3 was equivalent to 2× MIC of vancomycin, and all other concentrations of peptides were better than that with vancomycin.
The MIC of Ag-NPs for S. aureus and E. coli were 5 and 10 ppm, respectively.
Mycobacterium tuberculosis was very sensitive to 1e (R = C8H17) with MIC of 8 μg/mL.
Among the compounds, 2- 4-phenoxybenzamido -4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide (12- 4-phenoxybenzamido -4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamided was more potent than Ethambutol (MIC of 7.64 μM), Ciprofloxacin (MIC of 9.41 μM) and standard lead compound SID 92- 4-phenoxybenzamido -4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
In this study, MIC of Pb II) ions was found to be 80 ppm.
