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Map locations and primer sequences of the microsatellite loci were used according to the Mouse Genome Informatics (MGI) of the Jackson Laboratory, USA, and Mouse Microsatellite Data Base of Japan (MMDBJ).
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It was however, not possible to identify GD patients with MGUS on the basis of abnormal FLCs since 44% of GD patients with MGUS had both FLC levels as well as a FLC κ/λ ratio within the normal range.
The plasma miR-92a levels did not correlate with duration between the time of diagnosis of MGUS and the measurement of levels in this study (data not shown).
Interestingly, no specific molecular changes have yet been identified as associated with the progression of MGUS to MM: the genomic architecture of both diseases being remarkably similar.
At registration of MGUS in the DNPR, the median age of the 327 patients was 71.0 years (range 34.6 91.7 years), and 166 (51%) were men.
We do not have a control group to compare the prevalence of vertebral fracture of MGUS patients with the general population.
We conducted a systematic review of all studies investigating the prevalence and incidence of MGUS in the online database PubMed.
Our patient differed from the previous cases of TEMPI in that all previous reports were with IgG MGUS, with the exception of a recent case of renal lymphangiectasis, polycythemia and IgA MGUS who lacked cutaneous telangiectasia [ 15].
In conclusion, we found a high PPV of the MGUS diagnosis in the DNPR, which supports previous published register-based studies on MGUS and confirms that such administrative data constitute a strong tool for future epidemiological research in MGUS.
We estimated the PPV of the MGUS diagnosis based on this sample of 327 medical records.
No previous studies have formally addressed the validity and completeness of the MGUS diagnosis in a hospital registry.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com