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The modified SANS, containing glucosamine (150 mg), was selected for in-vivo studies as it had a sustained drug release profile and a small particle size (173.90 nm).
A formulation consisting RB (50 mg), HPMC K4M, PVA, and PEO (63 mg), glycerol (1.5 ml), stevia (5 mg) was selected as our optimum composition.
Cilengitide 2000 mg was selected for the subsequent randomized phase II part assessing progression-free survival (PFS).
No dose-response relationship was observed for efficacy or safety, and the lowest dose (25 mg) was selected for further clinical development.
Therefore, the relatively low oral dose of 0.5 mg was selected, considering that even this dose may produce a peak blood concentration well above the physiologic peak [ 26].
A dose of cilengitide 2000 mg was selected for the phase II study, which will assess PFS in a larger patient group.
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For our experiments Cu, Al, and Mg were selected as matrices.
8 Accordingly, two doses of OCR, 200 mg and 500 mg, were selected for further phase III investigation.
Twelve randomly selected insects weighing between 250 350 mg were selected for each isolate (Vanderhorst, Inc, St .Mary's, OH).
No DLT was seen, and irinotecan at 110 mg m−2 every 3 weeks in combination with epirubicin 60 mg m−2, and cisplatin 50 mg m−2 was selected as the recommended phase II doses for this triple combination.
The dose level of 0.8 μg m−2 NGR hTNF plus doxorubicin 75 mg m−2 was selected for phase II development.
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