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Etoricoxib 90 mg has been compared to etoricoxib 120 mg in two other prior post-operative pain settings.
Twenty-eight evaluable patients received a daily dose of 800 mg in two divided doses every 12 hours.
Microalbuminuria was diagnosed when the microalbumin excretion was ≥30 mg in two consecutive 24-h urine samples.
Study treatments were rofecoxib 50 mg (1330 patients), placebo (570 patients), and active comparators of ibuprofen 400 mg in six trials (303 patients), enteric-coated diclofenac sodium 50 mg in one (121 patients), naproxen sodium 550 mg in two (88 patients), paracetamol 600 mg plus codeine 60 mg in two (360 patients), and oxycodone 5 mg plus paracetamol 325 mg in two (180 patients).
In monotherapy, LPT has been used up to the daily dose of 1500 mg in two phase II studies (Blackwell et al, 2004; Burstein et al, 2008).
Rofecoxib 25 mg was tested in a single trial, rofecoxib 50 mg in three, ibuprofen 400 mg in one and naproxen sodium 550 mg in two.
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This cut-off point was reached after a cumulative dose of 200 mg m−2 in two patients, after 400 mg m−2 in four patients and after 500 mg m−2 in four patients.
Aluminium and REEs are separated from Ni, K, and Mg in three main extraction stages (70% Cyanex 923, 10% TBP, 10% kerosene, 10% 1-Decanol).
A standard protocol of 252 mg in seven 36 mg pellets placed at the uterine fundus on two occasions a month apart has now been widely used with considerable evidence for safety and efficacy.
Hyponatremia was observed within the first month, with dosages of 900 mg in one patient, 1200 mg in three patients and 1800 mg in the fifth patient.
Hosokawa et al. [6] showed the enhanced anticoagulant effect of warfarin after co-administration with oxycodone 10 mg in seven of nine patients, although the mechanism is not known.
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