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Also, TNF-α level in 1 mg and 10 mg groups was significantly higher than 100 µg group (p<0.001) (Fig. 7B).

Median PFS in the cediranib 20 and 30 mg groups was 5.8 and 7.2 months, respectively, compared with 7.8 months in the bevacizumab group.

The magnitude of improvement observed with the etoricoxib 60 and 90 mg groups was similar to that of the diclofenac group; the efficacy demonstrated by the etoricoxib 60 and 90 mg groups was slightly greater than that observed with the etoricoxib 30 mg group.

However, in the evaluation of cognitive function using MMSE score, the difference between the placebo and 10 mg groups was significant, which is consistent with the previous double-blind study [ 11].

24 The mean reduction in HbA1c from baseline for the placebo versus dapagliflozin 2.5, 5, and 10 mg groups was statistically significant (0.13% versus 0.58%, 0.63%, and 0.82%, respectively).

The mean percent change (±standard deviation) in sUA from baseline to the final visit for the febuxostat 40 mg, febuxostat 80 mg, and allopurinol 200/300 mg groups was -36.9% (±16.8), -48.1% (±20.0), and -31.1% (±16.0), respectively.

When normalized for body weight after 12-week Boc5 injection, the weights of white fat pads, as well as brown fat pad (1 and 3 mg groups), were significantly reduced (P<0.0001, P = 0.0164 and P = 0.0022, respectively) (Figure 1E).

Data from CZP 200 and 400 mg groups were combined for analysis.

In Part II (8 weeks); the placebo, etoricoxib 5 and 10 mg groups were reallocated to etoricoxib 30, 60, or 90 mg qd or diclofenac 50 mg t.i.d.

The mean walking distances in the dronedarone 400 mg and 800 mg groups were equivalent to placebo on Days 8 and 30 (Table  2).

The etoricoxib (120 mg, 90 mg) groups were non-inferior to ibuprofen 1800 mg/day for both the pain and morphine consumption endpoints (no formal testing was done to compare ibuprofen and placebo).