Sentence examples for mfn in from inspiring English sources

Rather, MUL1 acts by suppressing mfn in parallel to the PINK1/parkin pathway.

Recruitment of Parkin to mitochondria causes the ubiquitination of mfn in a Pink1-dependent manner.

In our initial experiments, ubiquitylation of mitochondrial substrates (e.g. Mfn) in primary neurons after CCCP treatment was below the threshold of detection.

Finally, knockdown of mfn in the background of parkin MUL1 double mutants almost completely rescues the thoracic indentation and mitochondrial phenotypes of parkin MUL1 double mutants.

Essentially all of the "increase" in relative Mfn in the double mutant is not due to an increase in Mfn at all, but rather a decrease in actin.

In our view, the present results show that the MFN in the UG is strongly context dependent and does not simply reflect the discrepancy between expected outcome and real outcome.

Knockdown of MUL1 results in an increase in Mfn levels in mouse cortical neurons.

Sensory threshold for at least one thermal modality was abnormal in 38 patients (57.5%) with SFN, in 10 patients (47.6%) with MFN and in 12 patients (54.4%) with LFN, comparing with healthy subjects.

Therefore, it is tempting to speculate that the "increased" mfn levels in pink1 or parkin knockdown flies may reflect an increase in mitochondrial biogenesis in these mutants [17].

In our study, CHX treatment leads to the stabilization of Mfn levels in HeLa cells lack of MUL1.

In the revision, we added Figure 3F to show that the increased Mfn levels in PINK1 mutants are reduced when MUL1 is overexpressed.