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The METRIC trial is a multi-centre prospective cohort study comparing the diagnostic accuracy of MRE and USS for the presence, extent and activity of small bowel Crohn's disease.
The METRIC trial achieved National Health Service research ethics committee (NHS REC) approval in September 2013 (13/SC/0394) and is being conducted in accordance with the principles of Good Clinical Practice (GCP).
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Cardiac magnetic resonance provides accurate and precise measurements of left ventricular structure [ 41, 42] and has been repeatedly employed as the metric in trials of intensified dialysis [ 7, 8, 37, 43].
The approval was based on phase III multinational, randomized trial METRIC [ 56, 57].
Hence, cache hit ratio follows a similar trend to the requests per surrogate metric, between the trials for the various algorithms.
That said, we agree that the single-trial metric of LFP ERP latency does seem like a nice innovation.
For each metric the number of trials is selected to minimize runtime while providing enough samples to generate meaningful results.
The STE, a trial-level metric, is a useful measure because it provides information on the surrogate endpoint in the units of the surrogate and therefore could be used to inform drug registration and drug reimbursement decisions that are based on surrogate endpoints.
We used number of successful strikes (strikes leading to consumption) per 10 min trial as our metric of consumption rate.
While the absolute proportions of patients achieving this degree of weight loss in clinical trials are an important metric for regulatory bodies, differences in lifestyle programmes between trials can make comparisons difficult.
Figure 6 presents the OSPA metric results over 100 Monte Carlo trials for r=10 with both algorithms.
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