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A similar clustering is also observed when using Pearson correlations to determine the distance metric (data not shown).
Deaths from motor vehicle accidents were not related to pesticide use with either exposure metric (data not shown).
However, broadly similar conclusions were obtained when using skew, kurtosis or a direct measure of correlation to normality as the summarization metric (data not shown).
We also observed that Htt93Q Glut1 RNAi flies have a significantly shorter lifespan compared with Htt93Q flies (P < 0.05) (Fig. 5D), while Glut1 overexpression has no effect on this metric (data not shown).
Curve fits were analogously constructed using the Iavg pooling metric with the paired method (with results similar to using the Imin metric, data not shown), and using both Iavg and Imin with the unpaired method (with results similar to using the ratio method with direct comparison arrays, data not shown).
Investigation of our proposed haplotype-based metric did not find its performance to be superior (in terms of power or type I error) to that of our correlation-based metric (data not shown), and thus, for the time being, we have not considered it any further.
Similar(54)
Metric values (data not shown) for all 18 samples analyzed were within the recommended value range indicating that hybridization quality was satisfactory.
Results of analysis using the yearly exposure metric were similar (data not shown).
Analysis using Spearman's rank correlation metric gave similar networks (data not shown).
We thus set out to develop a general clustering framework for any type or size of data (not necessarily metric), while maintaining the relative simplicity of hierarchical clustering.
For instance, when data are highly skewed, as in house prices or income, the median is the appropriate metric with which to summarize the data, not the mean.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com