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Cross-sectional DTI metric data for FA and MD are shown in Table 3 (see Supplementary Table 2 for RD and AX).
Bond metric data for this motif are consistent with significant delocalization of negative change between the phosphorus atom and the carbonyl moiety, observable in a shorter P1 C1 and longer C1 O1 distance (1.799 2) and 1.269 2) Å, respectively) relative to that of the N- prop-2-yn-1-yl phosphinecarboxamide precursor (P—C: 1.860(1) Å; C—O: 1.240(2) Å).
To determine the accuracy, sensitivity, and specificity of each DTI metric in classifying individual participants into separate groups (bvFTD or control), receiver operating characteristic curves were constructed using either raw DTI metric data (for baseline measurement) or the estimated mean difference in the rate of change for each diffusivity metric (for longitudinal measurement).
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Concurrent acquisition of fluorescence and reference signals allowed the efficient generation of ratio-metric data for 3D image reconstruction.
However, the discrete detector DOT approach has not yet been applied to ratio-metric data for fluorescence DOT.
As with their observations concerning body size, Berger et al. [1] appear to be unaware of the large body of comparative dental metric data available for East Asia, Southeast Asia, Indonesia, the Bismarck Archipelago, and Oceania in general [e.g., 20], [22], [61], [65].
The added stability is in a large part due to the possibility of delocalizing some of the negative charge over the carbonyl moiety, which is manifested in the bond metric data obtained for 6 (see below).
These data were supported by quantum chemical calculations at the DFT level, which showed a good agreement with the bond metric data obtained for the optimized computed geometry of 6.[ 21] Moreover, inspection of the Kohn Sham frontier orbitals showed that the HOMO is predominantly P=C π bonding in character and antibonding for the carbonyl moiety.
Kolmogorov-Smirnov tests were performed for all continuous metric data to test for normality.
All metric data were tested for normal distribution using the Shapiro Wilk W test. Normally distributed results of single measurements were compared between the groups using Student's t-test.
Comparison between the two groups was performed using the t test or the Mann-Whitney U test for metric data and the chi-square test for categorical data.
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