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The patient's past medical history showed use of methylphenidate (dosage varied with age) for approximately 17 years with voluntary cessation a few years ago.
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At baseline, methylphenidate dosages ranged between 18-180 mg, with a mean dosage of 60.5 mg.
In contrast, serum concentrations of methylphenidate increased rapidly after administration of a single OROS methylphenidate dose.
Dosage of methylphenidate was based on the body weight of the child (0.1 0.5 mg/kg/day).
Moreover, pretreatment at various dosages of methylphenidate also increased vulnerability to cocaine as well as to other addictive drugs [ 8, 10, 11].
The dosage range for methylphenidate was 36-162 mg, with a mean dosage of 62.5 mg.
The dosage range of methylphenidate at follow-up was 36-108 mg, with a mean dosage of 59.4 mg.
Previous studies showed that methylphenidate pretreatment at the 5 mg/kg dosage (i.p).
During this phase, OROS-methylphenidate delivered at a flexible daily dosage of up to 1.3 mg/kg body weight further improved outcomes within participants [ 40].
An initial 5-week randomized, double-blind, placebo-controlled phase with OROS-methylphenidate delivered 72 mg daily was followed by an 47-week open-label extension with OROS-methylphenidate delivered at a flexible daily dosage of up to 1.3 mg/kg body weight in all participants.
Outcomes continued to improve during the subsequent 47-week open-label extension with OROS-methylphenidate delivered at a flexible daily dosage of up to 1.3 mg/kg body weight.
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