Sentence examples for methylation variability between from inspiring English sources

Our analysis was not intended to show differences in methylation variability between NIDDM2/IFG patients and lean control subjects.

Recent studies have uncovered a large amount of DNA methylation variability between MZ twins (20, 21), supporting the notion that epigenetic variation may contribute to phenotypic discordance between genetically identical individuals.

Interestingly, recent epidemiological studies also identified some associations between LINE-1 methylation variability and ischemic heart disease and stroke [ 23], as well as with MetS phenotypes, such as plasma fasting glucose [ 24] and plasma lipid levels [ 24, 25].

Furthermore, although the 2-h post-OGTT glycemia explains between 19 and 28% of the DNA methylation variability at the leptin gene locus, a significant portion of the variability remains to be explained by other factors.

By the 7th passage, a slight increase in methylation variability was detected, but the correlation was only slightly lower than between replicates of the same passage.

DNA methylation variability at growth-related imprints does not contribute to overweight in monozygotic twins discordant for BMI.

Furthermore, the unsupervised hierarchical clustering using the top 500 CpGs with the highest methylation variability did not clearly distinguish RA from OA (Supplementary Figure S1e).

An association between DNA methylation and increasing age has also been reported, for example increased DNA methylation variability in older twins compared with younger twins and increasing variability with increasing age in familial clusters (37, 38).

It is interesting to highlight that, between the 4 regions that we have analyzed in IGF2/H19 locus, IGF2_shore is the one in which the scatter in methylation variability during aging is more evident.

We generalized the recent finding on methylation variability in cancer research to obesity and demonstrated that differential variability is also an important feature of obesity-related methylation changes.

Here, using BSP, we observed methylation variability in two CpG sites that may indicate cell-specific methylation.