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The discrepancy of DNA methylation profile between human and mouse might also suggest an evolutionary role.
Then, peak data were analyzed to compare the methylation profile between ectopic thyroids and orthotopic thyroids using the Loess normalized log2 (ChIP/input) ratios with the one-way ANOVA tool of the Partek Genomics Suite (PGS) software.
It is believed that the difference in DNA methylation profile between rodents and primates may account for the disparity of placentation, such as different degree of trophoblast invasiveness, between species.
A population-to-population comparison reveals a different methylation profile between Iranians and AA for: GPNMB (89 vs. 100%), CHD5 (47 vs. 78%), LGR6 (31 vs. 49%), and ICAM5 (7.5 vs. 40%) with at least 3 statistically significant differences (GPNMB, CHD5 and ICAM5).
We calculated pairwise correlations of the methylation profile between all possible pairs.
Furthermore, the majority of the PPARγ cistrome corresponded to the pre-set methylation profile between ADSCs and FatCs.
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We selected differentially methylated imprinted genes located on different chromosomes and showing opposite methylation profiles between tumors and surrounding tissues (MEST, H19, and KCNQ1 as well as GABRA5 promoters).
Hence, the difference in DNA methylation profiles between fibroblasts and MSC may also arise from a specific epigenetic make up of the multipotent subset within MSC.
To explore differences in DNA methylation profiles between tumor histologies, we compared the DNA methylation levels of 818 autosomal CpG sites selected for variability in DNA methylation levels across the tumors (see Methods).
The significant difference in DNA methylation profiles between ovarian cancer cell lines and tumors underscores the need to be cautious in using cell lines as tumor models for molecular studies of ovarian cancer and other cancers.
To investigate whether the difference in methylation profiles between breast tumors is related to differences in the DNA methyltransferase (DNMT) machinery, we compared the expression levels of DNMT1, DNMT3a and DNMT3b mRNAs between the high β and low β groups of breast tumors (Figure S1).
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