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We examined DNA methylation across four regions of the placenta to evaluate methylation levels of stress-related genes within a healthy placenta, and to evaluate whether methylation patterns vary by sampling location.
One of the surprising finds was how widely DNA methylation patterns vary in cells as they differentiate.
These results reveal that DNA methylation patterns vary markedly between cerebral and cerebellar cortices and further demonstrate that the genome of the cerebellum is hypomethylated as compared to regions of the cerebral cortex, suggesting a potential role for DNA methylation in brain organization and function.
DNA methylation patterns vary significantly throughout development.
In organisms that live in the marine world, sterol methylation patterns vary greatly and reflect the complexity of mixtures of sterols arising through the food chain.
On the other hand, it is expected that methylation patterns vary between different cell tissues and this would be masked by such normalization regimen.
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Promoter methylation pattern varies in different types of cancers.
The methylation pattern varied among the different cell lines as shown in Figure 1C.
Further, methylation patterns can vary on a clonal basis (7).
Other studies have shown that arsenic methylation patterns may vary by ethnicity (Vahter 2000, 2002).
Mode of delivery was evaluated for potential confounding or effect modifiers also because animal data suggests DNA methylation patterns may vary by delivery mode [ 33].
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