Sentence examples for methylation in various from inspiring English sources

Our findings of frequent ECRG4 methylation in various cancer cell lines may suggest that ECRG4 might be methylated in even other tumor types.

This result was not surprising, since a report regarding analysis of CpG methylation in various CpGs suggested their diversity by age, sex, and race [35].

Therefore, the detection and analysis of levels and patterns of genome-wide methylation in various tissues, is essential for understanding associations between tissue-specific methylation and tissue-specific gene expression.

There are many gaps in our knowledge regarding the function of DNA methylation in various genomic contexts such as promoters and gene bodies and the mechanisms by which DNA methylation can influence gene expression.

Most of the cancer-related genes included in this study show aberrant methylation in various types of neoplasia, including CNS tumors (Table S1), and hence we were interested to monitor potential methylation changes within these genes during the course of normal brain development and aging.

Furthermore, the genes showed 100% specificity with no methylation in various sources of healthy donors.

PcG mediated silencing is also suggested to predispose target genes to DNA-methylation in various cancers [14], [15], [16] consistent with the observation that the PRC2 complex interacts with DNMT1 and DNMT3A and B [17].

In contrast, in heart, liver and lung, the full methylation levels were higher than in muscle, spleen, kidney and stomach, but we found there were no significant differences in total methylation level, hemi-methylation level and full methylation level in various tissues (P>0.05).

The down-regulation of genes involved in methionine biosynthesis by pterostilbene may cause cellular stress by not only decreasing methionine levels, but also by compromising the supply of donor methyl groups required for methylation reactions in various biosynthetic pathways.

Recently, several studies concerning the relations between MGMT and MSI was reported (Whitehall et al, 2001; Laiho et al, 2002) and Yamamoto et al (2002) revealed that the sporadic colorectal cancers with MSI-H showed frequently methylation pattern in various genes and showed MGMT promoter methylation in 23% of the cases.

To investigate whether a systematic correlation exists between LTRs methylation status and transcriptional activities, we conducted paralleled transcription and methylation analyses in various cell lines, namely BeWo (choriocarcinoma), U937 (monocytes), 85HG66 (astrocytoma) and OVCAR-3 (ovarian carcinoma).