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The available data demonstrate widely varying levels of methylation in several insect species belonging to various orders and do not seem to indicate any conserved biological function [2].
Mood disorders and substance abuse disorders are risk factors for suicide and have also been linked to alterations of DNA methylation in several genes [24], [25], [36], [37].
Moreover, Caspase 8 is silenced by methylation in several other classes of cancer (Fulda, 2009).
In addition, we found longitudinal changes in DNA methylation in several genes encoding transcription factors (TFs).
Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML).
Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice lines.
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Interestingly, the methylation indexes in several tissues showed that the methylation profile of both DMRs is constant within an organ but varies significantly between tissues, i.e. muscle and tongue versus kidney for the H19 DMR or muscle versus tongue for the KvDMR1.
We therefore examined the stability of maintenance of DNA methylation imprints and determined the normal baseline DNA methylation levels in several adult tissues for all imprinted genes.
Differences in DNA methylation appeared in several gene promoters and more precisely: in 15 promoters when relapsing-remitting multiple sclerosis in remission [RRMS r)] was compared to healthy controls, in 14 when relapsing-remitting multiple sclerosis in exacerbation [RRMS e)] was compared to healthy controls, and in 5 when RRMS r) was compared with RRMS e).
Chronic inflammation has been associated with aberrant DNA methylation patterns in several tissues.
Bisulfite sequencing of clonal rDNA promoters has been used to characterize rDNA methylation status in several pathological conditions.
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