Sentence examples for methylation in regulatory from inspiring English sources

Since DNA methylation in regulatory regions is often a mark of gene silencing, we modified existing microarray-based assays to detect both methylated and unmethylated DNA sequences in the same sample, a variation we term the MAUD assay.

DNA methylation in regulatory regions, such as gene promoters and enhancers, is therefore inversely correlated with gene expression (Szyf 2010).

By using a microarray approach, we analyzed DNA methylation in regulatory regions of 806 cancer-related genes in 28 breast cancer paired samples.

DNA methylation in regulatory regions such as promoters and enhancers could silence gene expression, and an inverse correlation between gene expression and DNA methylation in promoters was proposed.

In Arabidopsis thaliana, CG DNA methylation in regulatory sequences is negatively correlated with gene expression [ 3, 19], possibly through limiting promoter accessibility.

It has been known for more than three decades that DNA methylation in regulatory regions such as promoters and enhancers can silence gene expression and that there is an inverse correlation between gene expression and DNA methylation in promoters [ 7].

Noncoding genomics, which ultimately controls the transcriptional machinery, includes single nucleotide polymorphisms (SNPs), DNA methylation, miRNAs in regulatory regions, and other noncoding RNAs, among other topics.

Active genes are usually associated with a relative undermethylation of CpGs in their regulatory regions (CpG islands [ 15]), and repressed genes are associated with a high level of methylation in their regulatory regions.

It is not only the degree of CpG methylation in the regulatory region of a gene, but also the distance of methylated CpGs from the transcription start sites that contributes to the repression of gene expression.

Profiles of CpG methylation in the regulatory regions of these genes were represented graphically in Figure 5. HLA-DR loci were completely methylated at all 9 CpG sites analyzed in Shef-1 and NT2 cells and this methylation status was maintained through the differentiation process.

Some endocrine disruptors may also modify DNA methylation in the regulatory region of specific genes.