Sentence examples for methylation in order from inspiring English sources
Therefore, it is reasonable to hypothesize that in cancer cells AP-2α may bind to specific target genes, silence transcription, and propagate DNA methylation in order to stably silence tumor suppressors and DNA repair genes.
According to the results, it is possible to define a reliable cut-off level (37%) in the mean methylation in order to discriminate histologically benign from malignant lesions.
We further assessed the effect of 5-Aza, a global inhibitor of DNA methylation, in order to validate our DNA methylation detection methods.
A similar state exists in mouse cells except that exon 2 of PolgA undergoes extensive DNA methylation in order for PolgA to be expressed.
Subsequently we calculated the ROC curve for mean methylation, in order to evaluate the potential value of the mean methylation percentage as a predictor of the status of malignancy as this is defined by the histological golden standard.
Subsequently, we performed a PATH analysis using the not imputed original dataset to test the complete model containing the variables skewing of XCI, age, log SEMs) and overall CpG methylation in order to understand the relations between them.
Moreover, a principal component analysis was performed on methylation data in order to identify and remove samples with aberrant methylation profiles.
Supervised and unsupervised clustering analyses with k-means algorithm were used to analyze aberrant methylation data in order to distinguish different subsets of CRCs based on LINE-1 and gene methylation levels.
Recent studies have suggested that HPV can modulate DNA methylation patterns in order to control cell proliferation.
In addition, we used both genetic variants and DNA methylation differences in order to explain the variability in transcript levels observed in adult livers.
Wilson et al. conducted whole-genome DNA methylation analysis in order to better understand the dynamics of HPV integration and its effect on both viral and host methylomes.
