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Cigarette smoke is an established environmental associate of DNA methylation (12– 17) and maternal smoking in pregnancy has recently been found to be associated with levels of DNA methylation in large-scale epigenome wide association studies (EWAS) of cord blood (18) and infant whole blood shortly after delivery (19).
Cavitation in large scale shear flows.
Cavitation in large scale shear flows.
We are interested in large scale effects.
Further studies in larger scale are required.
This information is useful for the identification of the genomic subset of CTCF sites that might contribute to differential cell- and stage-specific expression due to their sensitivity to cytosine methylation, potentially mediating changes in large-scale chromatin organization during development and disease.
The results clearly demonstrated that the F-MSAP technique can be adapted for use in large-scale DNA methylation detection in the pig genome.
DNA methylation has been identified as an important epigenetic control mechanism, particularly in large-scale gene silencing, such as X-inactivation [ 2], genomic imprinting [ 3], and silencing of transposable elements in plants [ 4, 5].
To reveal the relationship between dynamics of H3K9me2 and DNA methylation on a large scale, we compared genome-wide distributions of LOCKs (this study), PMDs in fibroblasts [ 14], and DNA hypomethylation blocks in colon cancer [ 20].
Cavitation in Large-Scale Shear Flows.
As a resource to study the potential roles of DNA methylation in mouse development, DevMouse could be extended with utilities for the identification and confirmation of developmental markers related to DNA methylation from large-scale methylome data (40).
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