Sentence examples for methylation in epigenetic from inspiring English sources

Considerable attention has recently been given to the functional role of DNA methylation in epigenetic inheritance.

The important role of methylation in epigenetic silencing is well established, particularly through regulatory mechanisms of transcription.

While knockout models demonstrated a role of Dnmt1 and Dnmt3 in mouse development [ 28, 29] and in general epigenetic phenomena, such as genomic imprinting [ 30], X-chromosome inactivation [ 31] and transposon control [ 32], the specific function of cytosine methylation in epigenetic gene regulation remains to be fully understood.

Such findings are in line with existing reports, which assert that arsenic exposure is associated with hypermethylation of promoter region CpG islands (Chen et al. 2001) and the well-established role of promoter CpG island methylation in epigenetic gene control and disease states (Ferreira et al. 2012; Lorenzen et al. 2012).

The objective of this study was to determine the tissue distribution of PPAR-γ in normal canine lung, canine lung cancer, and metastatic to lung cancer, as well as determine the role, if any, of DNA methylation in epigenetic control of gene expression.

Given the vital roles of DNA and histone methylations in epigenetic regulation of basic life processes in mammals, the dynamic and reversible chemical mA modification on RNA may also serve as a novel epigenetic marker of profound biological significances.

This work also provides new insight into the role of DNA methylation in multigenerational epigenetic effects, by showing heritable differences of DNA methylation between different chicken breeds [ 126].

While there is an established role for DNA methylation in the epigenetic regulation of gene expression, only limited data have been published regarding this relationship in human development.

Nevertheless, the fact that MeCP2 is associated with HMTs and HDACs supports a bidirectional and reinforcing interaction between DNA methylation and histone methylation in the epigenetic silencing of COX-2 in IPF.

The data strongly suggest that G9a- and EZH2-mediated histone methylation plays a central role and acts interdependently with DNA methylation in the epigenetic silencing of COX-2 in IPF.

Regardless of the hierarchical order of events, our observations support a central role for G9a- and EZH2-mediated histone hypermethylation and a model of bidirectional, mutually reinforcing, and interdependent crosstalk between histone hypermethylation and DNA methylation in the epigenetic silencing of COX-2 and potentially other antifibrotic genes in IPF (Fig. 9 ).