Sentence examples for methylation in determining from inspiring English sources

Heterozygotes typically exhibited heightened expression levels, suggesting a complex relationship between genotype and other factors (such as copy-number or methylation) in determining TERT expression levels.

There has also been relatively little in vivo or ex vivo study of the role of methylation in determining prognosis or response of rectal cancer to treatment.

A small number of studies have modelled the effect of radiotherapy upon colorectal cancer cells and the role of differential methylation in determining the response of these cells.

Moreover, patients presenting an EGFR promoter methylated tumour experienced in fact a worse clinical outcome thus confirming our hypothesis of a role for EGFR promoter methylation in determining the efficacy of anti-EGFR-targeted monoclonal antibodies.

These findings argue against a role for methylation in determining adult and childhood obesity, particularly as the MTHFR C677T TT homozygotes have been shown to exhibit a diminished level of DNA methylation compared with CC homozygotes (21).

However, the relatively small number of patients analysed in our series represents a clear limitation for a definitive conclusion about the role of EGFR promoter methylation in determining response to anti-EGFR treatments, and our findings should be considered speculative.

Of these only V35A, K36A and K36R affect PWWP-binding, suggesting limited involvement of the H3 amino acid sequence around the K36 methylation site in determining binding specificity.

We therefore estimated the relative importance of these ten factors and promoter/gene body methylation levels in determining the rate of mammalian protein evolution.

This suggests an important predictive role for MGMT promoter methylation status in determining optimal treatment among elderly GBM patients with favorable KPS for whom monotherapy with RT or TMZ is being considered.

Occasional families in which differences between affected and nonmanifesting subjects are minimal (for example, cohort 43), and variability in methylation levels between families, suggest that epigenetic factors in addition to DNA methylation are involved in determining if a subject will be clinically affected or disease nonmanifesting.

Considering that the methylation status participates in determining the morphological phenotypes of the cells [ 7, 28, 29], our results suggested an interdependence between cell-type and gene specific regulation of DNA methylations and morphological changes during EMT.