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Histone methyltransferases (HMTs), also referred to as protein methyltransferases (PMTs) since they methylate nonhistone proteins as well, are the methyl writers of the histone code.
HMTs, the methyl writers of the histone code, play a critical role in regulating gene expression and the chromatin state and have been implicated in many human diseases including cancer.
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The writers of this Dept.
Writers of the paper: BSAK and DG.
RC and EB were the primary writers of the manuscript.
Histone phosphorylation affects the affinity of readers or writers of other histone modifications.
RVS, NZ, LW and JR were the main writers of the manuscript.
They were the principal writers of the manuscript, and EJM did the analyses.
We suggest that adding a lysine or methyl-lysine mimic should be considered in the design of small-molecule inhibitors for other methyl-lysine writers, erasers, and readers.
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