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It is important to establish just how well the methods will perform in the hands of the analyst.
These methods will perform poorly in dynamic scenes.
Consequently, we expect that all AL methods will perform better than a selection process based on the random acquisition of files.
It is unclear how well any of these methods will perform in cases where the estimation model is a gross simplification of reality (as it often will be), or when certain parameters are assumed to be known without error.
The experiments carried out for up and down state separation show that histogram-based methods will perform well in ideal situations (as widely reported in the literature), but will fail if the signal differs from this harmonic, well-defined and non-trended behavior.
Also presented are cautionary notes about when examined methods will perform poorly.
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It is shown in the literature that an energy law preserving method will perform better for multiphase problems.
The purpose of QC samples in bioanalytical methods is to gauge how the method will perform for the analysis of post-dose test samples and hence, ideally, the relative concentrations of the analytes in QC samples should be selected to mimic the anticipated concentrations in the test samples.
Case 1: Suppose that (P y^{q},k_{q})=emptyset). Then the method will perform Step 5.
Since (k_{q}=k_{q_{0}}), the method will perform once Steps 3 and 4 to generate (y^{q}).
Case 1: Suppose that (P y^{q},k_{q})=emptyset). Then the method will perform Step 5. Assume that (k_{q}=0).
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