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METHODS:We tested the role of the transcription factor carbohydrate responsive-element binding protein (ChREBP) in fructose-mediated regulation of FGF21 using ChREBP knockout mice.
METHODS:We tested the association between genetic risk scores and each trait using summary statistics from published genome-wide association studies (GWAS) and from 51 537 cancer cases and 61 600 controls in the Genetic Associations and Mechanisms in Oncology (GAME-ON) Consortium.
We concluded that RF was the most robust and flexible among the imputation methods we tested.
Simulation study showed that this approach is more powerful in detecting multi-locus associations than other methods we tested, including one of ours.
Design and methods: We tested main and interactive relationships between delay discounting and relative reinforcing efficacy of food on zBMI discordance in 14 zBMI-discordant biological sibling pairs (6 female pairs) using a discordant sibling study design.
Methods: We tested the hypothesis in a population based group of 2105 Finns (1051 men, 1054 women) in five age strata (27, 37, 47, 57 and 67 years of age), all without clinically diagnosed cancer.
Methods: We tested the hypothesis that a homeopathic substance can bring about symptoms different from observation and placebo in a double-blind, placebo-controlled crossover design with baseline observation.
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As a proof-of-principle of this method, we tested it with recombinant antigen (human recombinant interleukin 8).
To validate the method, we tested it with the feature algorithm known as speeded up robust features (SURF), one of the most efficient approaches for feature extraction.
The method we tested is direct measurement of CO2 concentrations with a portable air-quality meter, which allows a large number of samples.
Using this method, we tested a total of 2 327 cattle from three dairy farms for the presence of BVDV persistently infected (PI) animals.
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