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The uniformity of coverage, crucial for optimal variant detection (Supplementary Methods), was calculated taking the standard deviation of read coverage to measure extreme high and low signals (Figure 1b).
The coefficient of variation for both methods was calculated.
The correlation between the two methods was calculated using the Pearson correlation coefficient.
A confidence value (CV, see Methods) was calculated to estimate the strength of experimental support for each predicted interaction.
The rCBF measures were plotted against each other for each subject individually using linear regression analyses; the linear slopes were determined; and the coefficient of determination [r2] between the two methods was calculated.
The detection limit (LOD) for the proposed methods was calculated using the following equation according to IUPAC definition (23): LOD = 3s/k; where s is the standard deviation of replicate determination values under the same conditions as the sample analysis in the absence of the analyte, and k is the sensitivity, namely the slope of the calibration graph.
Similar(16)
Alignment metrics reflecting WGS performances (Supplementary Methods) were calculated for 52 patients and compared (Wilcoxon signed rank test).
The capacity values using various methods are calculated.
Thresholds for all three methods are calculated with the hill climbing method.
The MI values of the four different methods are calculated and shown in Figure 6.
Most of the reported porosity measurement methods are calculated or analogical.
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