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A step forward to virus-free reprogramming methods was application of synthetic-modified mRNA [ 28] and recombinant proteins [ 29– 31].
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In general, these methods are application dependent and fall into two categories: parametric and nonparametric methods.
Model building methods are application oriented, varying from case to case.
In most cases, adaptation methods are application-specific and the challenge in this work is to make a general adaptation method for the field of industrial diagnostics applications.
It should be noted that the proposed method is application independent and can be used for other design problems.
The key point of the method is application of specially designed and optimized bell-shaped extraction device, BSED.
A key component of this method is application of the default noise filters of mzMatch.R and IDEOM to obtain a list of monoisotopic peaks representing putative metabolites present in the label-free sample.
Since each clustering method has its (dis)advantages, the choice of the most appropriate method is application-dependent (Fortunato, 2010).
Two application methods were tested: application by brush, a traditional method in paper conservation, and using a film applicator, based on the positive results obtained with adhesive processing during the preparation of remoistenable tissues [7].
An alternative and rapid method would be application of molecular techniques.
One of these unconventional methods is the application of ultrasound for oil reservoir stimulation.
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