Greater potency can be achieved using synergistic drug combinations, but drug pairs may have synergistic adverse effects as well [7].
The interaction of KW-2478 and bortezomib was determined by CI methods using the CompuSyn software program (ComboSyn Inc., Paramus, NJ, USA) to determine whether the combination was additive or synergistic.
This result appears to correlate with our initial purification method using the assay for synergistic hydrolysis of Avicel.
Several synergistic methods and the methods used to calculate synergy, have been reviewed [ 3].
Synergistic interaction between ozone and sulfuric acid aerosol was demonstrated to occur at environmentally relevant concentrations of both pollutants by several of the analytical methods used in this study.
To determine if the antitumor effects obtained with different AZD6244 and MK2206 combinations were synergistic, we calculated the combination index (CI) according to the Chou-Talalay method using Calculsyn software (Biosoft, Cambridge, UK).
To investigate the synergistic efficacy of the drug combination, the combination index (CI) was determined according to the Chou-Talalay method using CalcuSyn software version 2.1 (Biosoft) [ 23].
As the effects of IPTp and ITNs used during pregnancy have similar causal pathways for preventing stillbirth, and as there is no evidence of a synergistic effect between them [ 24], the data were pooled irrespective of method used.
The method used for synthesising P25 must ensure good contact between anatase and rutile in order to observe the synergistic effect between the two phases.
Another method uses mats.
