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A recursive search strategy in the NCBI and Ensembl databases using the complete repertoire of human s100 genes as reference set, in combination with retrieval of automated ortholog predictions (see Methods) uncovered a total of 97 fish s100 genes.
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Second, our classification method uncovered a high degree of variation in the repeat consensus sequence both within and between species.
In addition, our method uncovered a previously undetected modified histone site in the proximal promoter region of the CWF19-like one cell cycle control protein.
Thus, the two methods uncovered almost 40% more proteins compared to what is obtained by only one method.
While these dimensions show good consistency across our studies and are supported by the literature in the field, the quantitative and qualitative methods used also uncovered a rich variation in how the dimensions are construed by different stakeholder groups and along different reaches of the corridor.
Such analyses, when applied in the metabolic context, can be thought of as pathway finding methods, uncovering linked modules (or pathways) of genes or proteins that undergo coordinated change as a result of some environmental or genetic perturbation.
This paper describes statistical methods uncovering patterns in monthly pedestrian crashes aggregated on urban roads in Connecticut from January 1995 to December 2009.
While current methods uncover ever greater quantities of copy number variants (CNVs) relevant to complex phenotypes and using increasingly sophisticated sample designs, challenges persist in accurate and sensitive detection and confirmation of CNV calls.
We discuss how state-of-the-art methods are uncovering a range of genetic mechanisms, from rare mutations of large effect to common polymorphisms that increase risk in a subtle way, while converging on neurogenetic pathways that are shared between distinct disorders.
Many previous studies have successfully used these methods to uncover a large number of C2H2 ZNF gene families.
This observation may be consistent with that of [ 22] who found that a haplotype-based method uncovered Mendelian inconsistencies between second degree relatives more effectively than single-SNP approaches.
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