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Although he suggested certain technical methods to moderate the event while doing the surgical procedure he had no solution for absolutely preventing its occurrence.
Information is borrowed by constraining the within-block correlations to be equal between variables and by using empirical Bayes methods to moderate the standard deviations between them [ 48, 66].
On the basis of the impracticality of applying conventional methods to moderate FWER, the reduction (filtering) of the data set size of previous statistical testing is, in our opinion, mandatory.
EdgeR integrated three existing methods and introduced two novel methods based on MA-plots to detect and visualise gene expression difference, whereas DEGseq used empirical Bayes methods to moderate the degree of overdispersion across transcripts, improving the reliability of inference.
Differentially expressed (DE) genes between resistant and parental cell lines were selected with Limma package/R by fitting a linear model to the expression data for each gene and using empirical Bayes methods to moderate the standard errors across genes [ 70].
An additional random effect with two levels was fitted to control for the batch effect, and estimated borrowing information between features, by constraining the within-block correlations to be equal across features and by using empirical Bayes methods to moderate the standard deviations [ 57].
Similar(54)
The primary purpose of the performed research is to find a method to moderate the energy use without compromising the comforts of the inhabitants.
Limma uses an empirical Bayes method to moderate the standard errors of the estimated log-fold changes.
To identify differentially expressed genes, we used Bioconductor's "Linear models for microarray analysis" (LIMMA) [60] package which estimates the fold-change between DCs infected with different pox viruses by fitting a linear model and using an empirical Bayes method to moderate standard errors of the estimated log-fold changes for expression values from each gene.
Differential expression between Z females mated with Z versus M males was then assessed using a Student's t-test and an empirical Bayes method to moderate standard errors of the estimated log fold change, as implemented in the LIMMA package.
Differential gene expression between the groups in the initial data set and the replication data set was determined with the linear models for microarray data (limma) package and P-values were calculated with a modified t-test in conjunction with an empirical Bayes method to moderate the standard errors of the estimated log-fold changes [28].
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