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When measuring the appearance of exacerbations with these two methods, this trial is able to compare event based and symptoms based methods in relation to the primary and some of the secondary outcome measures.
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As in Trial 2 the ELISA-based methods in this trial were generally less sensitive than the other method.
The patients and the methods of this trial have been described in a previous paper [ 24]; in this paper, we described in detail the methods for evaluation of IOP and blood pressure and their analyses.
The methods of this trial have been described (15 ).
The detailed data collection methods for this trial have been previously described [ 26].
Detailed methods of this trial and its main outcomes are described elsewhere [ 32].
Methods: In this trial, zonisamide (400-mg daily) was administered to alcohol-dependent subjects (ADS) (n = 16) over 13 weeks.
The methods of this trial have been described in detail previously (Saltz et al, 2008; Cassidy et al, 2008a).
Details of patients and methods in this trial have been described previously by Francis et al. [ 20].
The design and methods of this trial have been reported elsewhere (24), as have the baseline characteristics of the randomized cohort (25).
Given the settings and methods in this trial, both practical and theoretical reasons made it impossible for such a randomisation to be applied.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com