In some cases, the internal validity of the primary studies was affected by competing risks and informative censoring, which violate the assumptions underlying the Kaplan Meier survival analysis method (these issues are discussed fully elsewhere in Hind et al, 2006).
The two classes of methods address these issues differently; e.g., continuum methods allow the user to input prescribed constitutive laws for the modeled materials, whereas the constitutive behavior 'emerges' from particle dynamics methods.
Progress of evaluation methods on these issues is shown with activities on verification and validation (V&V) and experimental studies towards commercialization of SFR in Japan.
Clinicians will remain dependent on serological methods until these issues are resolved, but work can be done to optimize their performance.
Moreover, where all the antibodies tested in specimens derived from same conditions (e.g. same animal)." Reply: A paragraph has been added to the Methods clarifying these issues.
The new method considering these issues needs to be calibrated with design codes and experimental tests.
The Achievable Benchmark of Care (ABC) method addresses these issues by identifying benchmark-setting surgeons with high levels of performance and greater case volumes.
The Dual-Temperature-Difference (DTD) method addresses these issues by utilizing the Two-Source Energy Balance (TSEB) model of Norman et al. (1995) [1], and is a relatively simple scheme requiring meteorological input from standard synoptic weather station networks or mesoscale modeling.
As demonstrated by our B73 × CG F2 population, even a simple imputation method resolved these issues by removing ambiguous data.
Our method overcomes these issues by estimating both phenotypic and genotypic evolution in an integrated framework over the entire tree.
