For this method, the rationale is that drugs with similar gene expression patterns are likely to share common target proteins.
In this method, the rationale for homology assessment is accounting for the fact that secondary structure is functionally constrained in ribosomal RNA.
We next compared an animal's preference for sucrose vs sucralose plus optogenetic activation of MCH neurons (see 'Materials and methods' for the rationale of concentrations chosen).
The effect of different standard preparation conditions was assessed by analysis of z-scores for estimated concentration, calculated as described below (see Methods, where the rationale for z-scoring is also presented).
(A – C ) Mice with ablated MCH neurons (red filled bars) and their respective controls (blue filled bars) were given the choice of (A ) 0.4 M sucrose vs 1.5 mM sucralose (*p<0.03, ¥p<0.011, see 'Materials and methods' for the rationale of concentrations).
We considered a shift in pI between human and mouse to be high if it was greater than 0.92, and an identical value between human and cow (Additional File 1; see Methods for the rationale behind the choice of these cut-offs).
In the blogosphere, the technorati are seeking answers from Google and Apple about their methods, and the rationales behind those methods, for dealing with location information derived from cellphone GPS applications as well as from the traditional constant contact that cellphones maintain with cellphone towers.
To address this problem we developed a new method, applying the rationale of multiple subpial transection (MST) to the hippocampus.
Therefore with this study we provide a versatile method and the rationale for controlling, at the atomic level, the nature of the interface of graphene/metal oxide nanocomposites.
The RIM method follows the rationale of using real observable outcomes to derive the index and employs two statistical procedures: K-means cluster analysis and discriminant analysis (Li et al. 2005; Li 2011; Lam et al. 2015a, b).
