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These include an enhanced graphical user interface, an improved Bayesian synthetic feasibility filter, new visualization methods, the inclusion of various drug-like, lead-like and unwanted substructure filters [75], and the possibility of generating morphs containing only user-defined substructures.
The alternative methods of evaluating the vibration (use of different frequency weightings, different averaging methods, the inclusion of different axes, vibration dose values and equivalent r.m.s. acceleration) as defined in the standards have been compared.
The methods, the inclusion and exclusion criteria, and the outcomes of interest were described in a pre-published protocol.
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For the 'REINFORCE + Prior' method, the inclusion of the prior likelihood in the reward function means that this is no longer a viable strategy (the sequences would be given a low prior probability).
Detailed discussion of the recruitment method, the inclusion and noninclusion criteria, the sample size, and the questionnaires used appears in the Appendix.
We estimated the importance of the different elements constituting our method: the inclusion of protein dynamics is essential; the local description allows the extraction of otherwise undetectable motions, and the discrete state model significantly improves the identification of relevant correlations.
In the complementary stepwise selection method, the inclusion of probes followed the same rules as in the forward method but a probe only remained in the model if its P-value was lower than the significance levels for stay of 10%.
Mixed methods, with the inclusion of Rasch, provided valuable evidence to support selection of the 'best' administration method for people with PUs during early PRO instrument development.
Mixed methods, with the inclusion of RMT, provided both qualitative and empirical evidence for selection of the 'best' administration method for people with PUs.
More intricate sampling methods and the inclusion of string arrangements meant that the production featured on the album was unique to hip-hop music.
DNA was extracted from blood samples by routine methods with the inclusion of a second proteinase K digestion at 50°C.
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