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This agreement has eluded previous authors, because their numerical methods suffered from grid effects and their linear stability theory was incorrect.
From this visual comparison, it is clear that most conventional methods suffered from zipper effects along the edges.
However, these reported methods suffered from using solvents of high cost, time-consuming extraction procedure and long chromatographic retention time.
These methods suffered from the problem of the activity cliff, which is defined as pairs of structurally similar molecules with large differences in potency [33, 34].
Although EDI-based methods needed more time than LFI-based methods due to requiring many operations to estimate the edge direction, the EDI-based methods provided high-quality results and the LFI-based methods suffered from jagged edge artifacts in the diagonal edge regions.
However, all six methods suffered from over-sensitivity.
Similar(52)
However, in the context of gene expression, clustering methods suffer from three main drawbacks.
Classical statisticians argue that for this reason Bayesian methods suffer from a lack of objectivity.
In addition, classical methods suffer from resolution limits which we hope to surpass.
The results from such methods suffer from inaccuracy, subjectiveness, untimeliness, and lack of reproducibility.
These methods suffer from various challenges such as illumination changes and dynamic background.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com