Instead of evaluating the similarity between individual features and class labels, wrapper methods seek for a best subset of features by evaluating the subset as a whole based on classification performance.
The reason that we did not filter out the outlier data in advance is that we believe some outliers have biological relevance, just like what the COPA methods seek for, which is not caused by experimental issues.
The proposed method seeks for a trade-off between the backbone transmission delay and the backbone lifetime.
To guide national public health bioterrorism preparedness and response efforts, a method was sought for assessing potential biological threat agents that would provide a reviewable, reproducible means for standardized evaluations of these threats.
However, as experimental methods are poorly amenable to genome wide analysis, computational methods have been sought for identifying MAR.
As the world has experienced a global spread of S-OIV since April 2009, methods have been sought for the real-time assessment of virulence by measuring the cCFR which is a representative of the epidemiological measurements of virulence [2], [3].
Fan [9] developed a new algebraic method, belonging to the class of subequation methods, to seek for more new solutions of nonlinear partial differential equations that can be expressed as a polynomial in an elementary function which satisfies a more general subequation than other subequations like Riccati equation, first-kind elliptic equation, and generalized Riccati equation.
Hypothesis-driven methods typified by inferential statistics have been gradually complemented or even replaced by data-driven model-free methods that seek for structure in data without reference to the experimental protocol or prior hypotheses.
Thus by these subequation methods we seek for the solutions of the nonlinear partial differential equations in consideration as a polynomial in one variable satisfying equations (named subequation), for example, Riccati equation, auxiliary ordinary equation [7], first kind elliptic equation, generalized Riccati equation [8], and so on.
Therefore, alternative methods had to be sought for a definite answer, such as "locking" the mutL gene to prevent it from conversion between the wild type and 6bpΔ mutL alleles and then inspecting overall mutability changes of the bacterial population.
