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Nuclei are quite unlike cities their structure changes from moment to moment and current high-throughput methods sample cell populations to yield data on an 'average' structure that probably never exists in any cell at any time.
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This method uses a sample cell and an in-situ FTIR to obtain the time profiles of dynamic interactions of adsorbing species on NP samples.
The magnetic-field-induced birefringence of the as-prepared ferronematic samples can be measured by the light extinction method, which consists of a sample cell placed between accurately set 'crossed' polarizers as shown in Figure 1[29].
Conventional cytology and both LBC systems share the same method of sampling cells from the cervix (i.e., scraping off cells with a brush or similar device from the histological transition zone).
In the first method, multiple protein samples (cell lysates) are spotted in arrays in register with the wells of a 96-well chamber apparatus.
However, this method requires cell solubilization, and the sample cells are killed and, thus, cannot be used for another assay.
To provide proof-of-principle that epidermal genetic information retrieval (EGIR™; DermTech International, La Jolla, CA, U.S.A ., a method that noninvasively samples cells from stratum corneum by means of adhesive tape stripping, can be used to discern melanomas from naevi.
Two recent multiphoton microscopy studies used refined methods for identifying hematopoietic Ag sampling cells in the intestine 44, 45.
With the same sampling method the cell type composition of the cultures was evaluated at 1 and 7 DIV on 3 coverslips from 3 distinct experiments.
Here, we report a method for normalizing expression data across samples and methods to the cell number of each sample, using the DNA content as indicator.
Furthermore, it remains unclear which method of sample preparation and cell extraction is most suitable for immunomagnetic enrichment and detection of CTC.
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