While this method requires increased skills in mapping, and is more complicated in its execution, it reduces the likelihood of selection bias that could arise if physiotherapists were allowed to select the households that they are to attend through the random walk method[ 18].
That will require increased financing.
Sustainability will require increased specialistion, too.
All of this requires increased resources.
In fact, since the Prony signal model does not include noise, Prony-based methods require an increasing number of M in the presence of so many small spectral components and noise.
However, these methods require considerable increase in bandwidth, longer end-to-end delay, or may require modifications on the sender side [9].
Intra-articular injections of corticosteroids and hyaluronic acid are currently used to treat chronic pain, but these methods require multiple injections that increase the risk of iatrogenic joint damage and other complications.
These relatively complex methods require specialized equipment and increase production costs.
While significant progress has been made in the detection of small numbers of proteins [1] [3] and in miniaturizing reaction volumes [4], these methods require specific antibodies and usually increase time and cost of an assay.
